Impact of the ATF6 pathway on senescent phenotype establishment and pro-tumorigenic effects - Bibliographic project
 

The endoplasmic reticulum is the central organelle of the secretion pathway. However, several elements can disrupt its functioning, putting the endoplasmic reticulum in a state of stress. An adaptive response, the Unfolded Protein Response (UPR) will then be initiated. There are three signaling pathways associated with UPR, including the ATF6 protein pathway. ATF6 is a transcription factor mainly known to regulate the expression of different chaperone proteins. However, this protein also play an important role in the development of cells senescent phenotype and have a pro-tumorigenic role in the development of different cancers. Recent studies have highlighted the key role of ATF6 in the establishment and maintenance of tumor micoenvironment, which promotes tumor development, resistance to treatment and mobility of cancer cells.

During this presentation, you discover the molecular link between the stress of the endoplasmic reticulum, the implementation of the senescent phenotype of cells, and some pro-tumorigenic effects.