Role of the GATOR complex in mitochondrial function - UMR 9018 CNRS, METSY Laboratory - Villejuif

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The SEA complex and its mammal homologue the GATOR complex are proteic complexes that were first described around ten years ago. During this past decade, their role as an upstream regulator of the mTOR (also known as mTORC1) pathway was defined. The mTORC1 pathway regulates cellular response to different stresses, and is for example involved in the regulation of mitochondrial homeostasis. The tumor suppressor role of several GATOR components was described as well.

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Preliminary data of the team showed that cells HEK293 and BEAS cells deleted for GATOR proteins show an increased cisplatin (an anticancerous drug) resistance and an altered mitochondrial network. During the internship, we will study the effect of various stresses on mitochondrial fate, and locate the proteins of the GATOR complex as well as the mitochondrial network structure in cells treated with cisplatin.